FC6 seems like a great release. Install is smoother than ever, not quite as beautiful as ubuntu, but no hitches.
I've tried it on a Dell desktop, a Dell laptop, and my MacBook (via BootCamp). I couldn't get wireless going on the Apple laptop which is a showstopper for me, but the cool new "Desktop Effects" did work while they didn't on the other two machines.
Desktop effects so far seems to make windows and menus "wiggle" in to view. I guess this is the beginning of the effects we've come to expect in MacOS X and soon Vista.
The web browser is Firefox and is as good an experience as it is anywhere. Now that I use Google Browser Sync, I can jump from machine to machine and feel right at home with all my bookmarks and even cookies following me around.
On the software side, I enabled IPV6 and have had trouble with WebService clients that used to connect to "localhost" that now need "127.0.0.1" for some reason. Yes it's in /etc/hosts.
What a great set of default apps you get. The OpenOffice suite is looking fantastic and any MS Office user would feel right at home.